연축성발성장애의 병리학적 발병기전을 밝혀낸 연구논문 국제학술지 발표 - 최신연구활동

Conclusions: These results show that laryngeal inflammatory reactions may induce the 
expression of proinflammatory cytokines along the afferent laryngeal circuit and in nuclei 
associated with the HPA axis. Local laryngeal inflammation may induce functional and 
physiologic alterations in the laryngeal neural system via neuroimmunologic reactions.

Objective: Idiopathic laryngeal disorders associated with various neurologic conditions 
such as spasmodic dysphonia, idiopathic vocal fold paralysis and sudden infant death 
syndrome are causally related to upper respiratory tract infections, and it can be 
speculated that these disorders result in neurophysiologic alterations. The goal of this 
study was to identify the neurophysiologic effect on the central nervous system 
of local inflammatory alterations in the larynx.

Material and methods: The expression of c-fos and IL-1β was identified after injecting 
saline solution, 10 μg of lipopolysaccharide or 100 μg of lipopolysaccharide into the larynx of 12 rats.

Results: The inflammatory cytokine IL-1β was mainly expressed in the inferior olivary 
nucleus and raphe nucleus, which are associated with the hypothalamic-pituitary-
adrenal (HPA) axis. IL-1β expression was also found in the nuclei of afferent nervous 
pathways of the superior laryngeal nerve, such as the nucleus tractus solitarius, 
nucleus ambiguus, lateral reticular nucleus, magnocellular reticular nucleus 
and paragigantocellular reticular nucleus.